Antiproliferative withanolides from the Solanaceae: A structure–activity study
نویسندگان
چکیده
منابع مشابه
Anti-proliferative withanolides from the Solanaceae: a structure-activity study.
As part of our search for bioactive compounds from plant biodiversity, 29 withanolides (1, 3-6, 9, 12-18, and 20-35) were recently isolated from three members of the Solanaceae: Physalis longifolia, Vassobia breviflora, and Withania somnifera. Six derivatives (2, 7, 8, 10, 11, and 19) were prepared from these naturally occurring withanolides. All compounds (1-35) were evaluated for in vitro ant...
متن کاملAntiproliferative withanolides from Datura wrightii.
A new withanolide, named withawrightolide (1), and four known withanolides (2-5) were isolated from the aerial parts of Datura wrightii. The structure of compound 1 was elucidated through 2D NMR and other spectroscopic techniques. In addition, the structure of withametelin L (2) was confirmed by X-ray crystallographic analysis. Using MTS viability assays, withanolides 1-5 showed antiproliferati...
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Since the isolation of withaferin A in 1965 over 300 withanolides have been described, largely from genera belonging to the Solanaceae. Although until the mid eighties most of the withanolides appeared to adhere to the basic structure of withaferin A, nowadays a considerable number of withanolides and withanolide related compounds are known, which present modified skeletons, aromatic rings, add...
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ژورنال
عنوان ژورنال: Pure and Applied Chemistry
سال: 2012
ISSN: 1365-3075,0033-4545
DOI: 10.1351/pac-con-11-10-08